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一名科学家因为发现新型人体基因，荣获医学大奖，但他还不满足，还非法用人体做实验，不想实验出现了意外，没想到会失败的他经常过度饮酒。由于一次酒驾撞死一家三口，他被吊销执照，弄得妻离子散。失意的他不小心把装满“新型人体基因”的试管打翻，流入下水道，污染了当地的水源。一些人饮用后，身体发生变异，开始疯狂噬咬同类......Linda开车遇上了车祸晕了过去，醒来后四处找女儿，却不想引来了丧尸的追逐......一些黑帮分子正在窝点娱乐，碰上进108区救人的SWAT队员并发生枪战，以为是来围剿他们的。然而，当尸群来袭，他们只得同心协力......因在黑道老板的夜店贩卖毒品，2个来台湾闯荡的外国人被绑在了地下室，看到外面丧尸来袭，2人拼命合力逃脱......在这个丧尸横行的108区，这些生还者最终只剩下了3人被姗姗来迟的军队指挥官所救，而他们，只是暂告安全......
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